Pharmaceutical API Raw Material CAS71125-38-7 Meloxicam

Basic Info

Model NO.	Meloxicam 71125-38-7
CAS No	71125-38-7
Mf	C14h13n3o4s2
Appearance	White Powder
Grade Standard	Medicine Grade
Shelf Life	2 Years
Transport Package	Bag, Carton, Drum
Specification	25kg/drum
Trademark	Arshine
Origin	China
HS Code	2941101900
Production Capacity	200 Tons/Year

Product Description

Pharmaceutical API Raw Material CAS71125-38-7 Meloxicam Meloxicam, a non-steroidal anti-inflammatory agent, has been reported to inhibit the inducible isoform of Cox-2. Meloxicam is an inhibitor selective for Cox-2 (IC50 of 4.7 μM) over Cox-1 (IC50 of 36.6 μM). Studies suggest that Meloxicam is Cox-2 preferential,therefore it will probably not display a lower gastrointestinal toxicity than non-selective anti-inflammatory agents. This compound has been shown to also inhibit prostanoid synthesis in inflammatory cells. Additionally, Meloxicam has demonstrated the ability to non-competitively inhibit erythrocyte PGD (6-phosphogluconate dehydrogenase) activity in vitro. Meloxicam, a non-steroidal anti-inflammatory agent, has been reported to inhibit the inducible isoform of Cox-2. Meloxicam is an inhibitor selective for Cox-2 (IC50 of 4.7 μM) over Cox-1 (IC50 of 36.6 μM). Studies suggest that Meloxicam is Cox-2 preferential,therefore it will probably not display a lower gastrointestinal toxicity than non-selective anti-inflammatory agents. This compound has been shown to also inhibit prostanoid synthesis in inflammatory cells. Additionally, Meloxicam has demonstrated the ability to non-competitively inhibit erythrocyte PGD (6-phosphogluconate dehydrogenase) activity in vitro.
Meloxicam is a non-steroidal antipyretic and analgesic anti-inflammatory drug, not a hormonal drug. It has strong anti-inflammatory, analgesic and antipyretic effects, and can selectively inhibit cyclooxygenase-2 (COX-2). Activity, thereby blocking prostaglandin synthesis, inhibiting prostaglandin biosynthesis at the Chemicalbook site of the inflammatory department is stronger than prostaglandin biosynthesis in the gastric mucosa or kidney, and is more safe than other NSAIDs. It is mainly used to relieve the symptoms of osteoarthritis, painful osteoarthritis, rheumatoid arthritis and joint spondylitis.For rheumatoid arthritis, rheumatoid arthritis, osteoarthritis, soft tissue injury and pain. The overview, pharmacological effects, pharmacokinetics, synthesis, and use of meloxicam were edited by Shi Yan of Chemicalbook. (2015-11-23 Chemicalbook)Adverse reactionsIndigestion, abdominal pain, nausea, diarrhea, elevated liver enzymes, dizziness, headache, rash, and anemia can occur. Occasionally edema, elevated blood pressure, mild serum creatinine or urea nitrogen abnormality, acute renal failure, gastric ulcer, gastric bleeding, gastric perforation, leukocytes, and thrombocytopenia.

PRODUCT NAME
TEST ITEMS	SPECIFICATION	RESULTS
Description	White Or Almost White Crystalline Powder	White Powder
Identification	Infrared Absorption	Positive
Assay	97.0~103.0%	99.2%
Melting Point	33~37ºC	34.5~36.5ºC
Loss On Drying	0.5%max	0.30%
Organic Volatile Impurities	2500PPm max	<1000PPm
Residual Solvents	Meet the requirements.(USP29)	Confirms
Chromatographic purity	sum of impurities:3.0%max	<3.0%
Conclusion	The specification conform with USP32 standard